Brain disease and network reorganization

Brain Atrophy and Reorganization of Structural Network in Parkinson's Disease With Hemiparkinsonism

Non-monotonic reorganization of brain networks with Alzheimer's disease progression

BACKGROUND Identification of stage-specific changes in brain network of patients with Alzheimer's disease (AD) is critical for rationally designed therapeutics that delays the progression of the disease. However, pathological neural processes and their resulting changes in brain network topology with disease progression are not clearly known. METHODS The current study was designed to investig...

From network structure to network reorganization

Networks can be dynamical systems that undergo functional and structural reorganization. One example of such a process is adult hippocampal neurogenesis, in which new cells are continuously born and incorporate into the existing network of the dentate gyrus region of the hippocampus. Many of these introduced cells mature and become indistinguishable from established neurons, joining the existin...

Brain reorganization following weight loss.

The long-term stability of bodyweight despite wide variation in energy intake and expenditure suggests that at usual weight energy intake and output are 'coupled' to maintain body energy stores. Our model for some of the molecular mechanics of this regulation of energy stores is based on the concept of a neurally encoded 'threshold' for minimum body fat, below which compensatory physiology is i...

Brain network interactions in health and disease.

Understanding how brain systems interact to produce complex behaviors is a central goal of cognitive neuroscience. Palaniyappan and colleagues enhance our understanding of how interactions among brain systems contribute to individual differences in function and psychopathology by examining causal interactions among the salience and central executive systems in schizophrenia.